In the field of plastic surgery, various forms of silicone implants are prevalently used recently, but the safety or effectiveness of it´s fluid form, when used in vivo, has not been cl: arly understood yet. Especially a little is known with regard to the absorption, distribution, excretion and ultimate fate of injected silicone. Only a few reports concerning the visceral response to injected silicone are available up to date and furthermore experimental animals were only limited to mice.
Therefore, the purpose of present work is to eiucidate histopathologically the local tissue response as well as systemic visceral response of Japanese D. M. P. S. Fluid in the rats. Liquid silicone were injected into the wall of abdomen and ear in the experimental animals. A group of animals were sacrificed on 1st, 4th and 12 weeks after the injection respectively and a specimen were taken from injected sites for local tissue response, similarly liver, spleen, kidney and lung for systemic response. Accordingly control group were injected with physiological saline and treated. All specimens were treated with hematoxilin and eosin as well as trichrome stains for histopathologic evaluation.
The results obtained were as follows;
A. Local Tissue Response
1. The injected silicone formed multiloculated cysts which were encapsulated by relatively thin fibrous tissue, and large swollen macrophages with intracellular clear vacuoles were observed in the surrounding tissue of cyst.
2. The fat cells surrounding the cyst were shrunken and atrophic.
3. Perichondrium and cartilage were not influenced.
4. Tiny cysts were found in the subsequent muscle layer.
B. Visceral Response
1. Atypical, large renal tubular cells, which were pinkish cytoplasm, a large nucleus rrith prominent nucleoli and contained coarse chromatin, were observed here and there in the cortex near the corticomedullary junction in 5 cases out of 15 kidney specimens.
2. One of the liver specimen(after 12 weeks) showed atypical large cells without interfering the hepatic lobular structure.
|